Tyrphostin A25

Description: Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 µM for GPR35 and an EC50 value of 5.3 µM for GPR35. Target: EGFR, GPR. Smiles: C(=C(C#N)C#N)C1=CC(O)=C(O)C(O)=C1. References: Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994,127(3):859-866.