TVB-3166

TVB-3166 is an inhibitor of fatty acid synthase (FASN, IC50 = 0.042 µM). It inhibits the biosynthesis of palmitate (Cay-10010279) in Calu-6 non-small cell lung cancer (NSCLC) cells and MRC-5 lung fibroblasts in a concentration-dependent manner. TVB-3166 (0.2 µM) induces apoptosis in Calu-6, as well as 22Rv1 prostate cancer, cells. It reduces tumor growth in an OVCAR-8 mouse xenograft model and K-Ras-wild-type or -mutant patient-derived xenograft (PDX) mouse models when administered at a dose of 60 mg/kg. TVB-3166 (50 mg/kg) also reduces lung viral titers in mice infected with respiratory syncytial virus A (RSV-A).Formal Name: 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-benzonitrile. CAS Number: 1533438-83-3. Molecular Formula: C24H24N4O. Formula Weight: 384.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5 mg/ml. lambdamax: 234 nm. SMILES: N#CC1=CC=C(C2CN(C2)C(C3=CC(C4=NNC(C)=C4C)=C(C)C=C3C)=O)C=C1. InChi Code: InChI=1S/C24H24N4O/c1-14-9-15(2)22(10-21(14)23-16(3)17(4)26-27-23)24(29)28-12-20(13-28)19-7-5-18(11-25)6-8-19/h5-10,20H,12-13H2,1-4H3,(H,26,27). InChi Key: ICDQFUFDAFKCAX-UHFFFAOYSA-N.