TTNPB

TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.Formal Name: 4-[(1E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]-benzoic acid. CAS Number: 71441-28-6. Synonyms: AGN 191183, Arotinoid Acid, Ro 13-7410. Molecular Formula: C24H28O2. Formula Weight: 348.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 229, 303 nm. SMILES: CC1(C)C2=C(C=CC(/C(C)=C/C3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1. InChi Code: InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+. InChi Key: FOIVPCKZDPCJJY-JQIJEIRASA-N.