Tryptophol

Tryptophol is an indole that has been found in plants, bacteria, fungi, and sponges and has diverse biological activities, including antifungal, sleep-promoting, and quorum-sensing-related properties. Tryptophol (100 µM) inhibits the growth of the chytrid fungal skin pathogens B. dendrobatidis and B. salamandrivorans in vitro. As a quorum-sensing molecule, it also induces autostimulation and increases tryptophol production in B. dendrobatidis and B. salamandrivorans cultures when used at a concentration of 1 µM. Tryptophol (400 mg/kg) induces sleep in mice as assessed by loss of the righting reflex.Formal Name: 1H-indole-3-ethanol. CAS Number: 526-55-6. Synonyms: IEA, NSC 3884. Molecular Formula: C10H11NO. Formula Weight: 161.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 223, 284 nm. SMILES: OCCC1=CNC2=CC=CC=C21. InChi Code: InChI=1S/C10H11NO/c12-6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11-12H,5-6H2. InChi Key: MBBOMCVGYCRMEA-UHFFFAOYSA-N. Origin: Synthetic.