Trimipramine (maleate)

Trimipramine is a tricyclic antidepressant. It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT, Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine H1 over H2, H3, and H4 receptors (Kis = 0.04, >100, and 43.6 µM, respectively). Trimipramine binds to muscarinic acetylcholine and alpha1- and alpha2-adrenergic receptors (Kds = 58, 24, and 580 nM, respectively), as well as dopamine D1 and D2 receptors and 5-HT receptor subtypes 5-HT1C and 5-HT2 (Kis = 346.7, 57.5, 537, and 19.5 nM, respectively). It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg. Formulations containing trimipramine have previously been used in the treatment of depression.Formal Name: 10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine, (2Z)-2-butenedioate. CAS Number: 521-78-8. Molecular Formula: C20H26N2 . C4H4O4. Formula Weight: 410.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 211, 248 nm. SMILES: CN(C)CC(C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22,5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: YDGHCKHAXOUQOS-BTJKTKAUSA-N.