Trimethoprim-d3

Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim (Cay-16473) by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid. Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.Formal Name: 5-(3,5-dimethoxy-4-(methoxy-d3)benzyl)pyrimidine-2,4-diamine. CAS Number: 1189923-38-3. Molecular Formula: C14H15D3N4O3. Formula Weight: 293.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC([2H])([2H])[2H]. InChi Code: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)/i3D3. InChi Key: IEDVJHCEMCRBQM-HPRDVNIFSA-N.