Trilostane

3beta-hydroxysteroid dehydrogenase (3beta-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3beta-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3beta-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3beta-HSDs: 3beta-HSD1 and 3beta-HSD2 with Ki values of 0.10 and 1.60 µM, respectively. Trilsotane has been approved for use in the treatment of Cushing's syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3beta-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.Formal Name: 4alpha,5alpha-epoxy-3,17beta-dihydroxy-androst-2-ene-2-carbonitrile. CAS Number: 13647-35-3. Synonyms: Desopan, Modrefen, Vetoryl, WIN 24,540. Molecular Formula: C20H27NO3. Formula Weight: 329.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 16 mg/ml. lambdamax: 252 nm. SMILES: OC1=C(C#N)C[C@@]2(C)[C@@]3(CC[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@H]5O)[C@@H]1O3. InChi Code: InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1. InChi Key: KVJXBPDAXMEYOA-CXANFOAXSA-N.