Trifluoperazine (hydrochloride)

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for alpha1 over the alpha2 subtypes (Kis = 24, 653, 163, and 391 nM for alpha1A, alpha2A, alpha2B, and alpha2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.Formal Name: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, dihydrochloride. CAS Number: 440-17-5. Synonyms: SKF 5019, TFP. Molecular Formula: C21H24F3N3S . 2HCl. Formula Weight: 480.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 260, 313 nm. SMILES: CN(CC1)CCN1CCCN2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C42.Cl.Cl. InChi Code: InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24,,/h2-3,5-8,15H,4,9-14H2,1H3,2*1H. InChi Key: BXDAOUXDMHXPDI-UHFFFAOYSA-N.