Trichostatin A

Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.Formal Name: 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide. CAS Number: 58880-19-6. Synonyms: TSA. Molecular Formula: C17H22N2O3. Formula Weight: 302.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M HCl: 1.3 mg/ml, DMF: 2 mg/ml, DMSO: 2 mg/ml. lambdamax: 265, 340 nm. SMILES: CN(C)C1=CC=C(C([C@H](C)/C=C(C)/C=C/C(N(O)[H])=O)=O)C=C1. InChi Code: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1. InChi Key: RTKIYFITIVXBLE-QEQCGCAPSA-N.