Triamterene

Triamterene is an inhibitor of the epithelial sodium channel (ENaC, IC50 = 4.5 µM for the rat channel). In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats. Formulations containing triamterene have been used in the treatment of edema. This product is also available as an analytical reference standard (Cay-22486).Formal Name: 6-phenyl-2,4,7-pteridinetriamine. CAS Number: 396-01-0. Synonyms: NSC 77625, SKF 8542, 2,4,7-Triamino-6-phenylpteridine. Molecular Formula: C12H11N7. Formula Weight: 253.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 232, 271, 367 nm. SMILES: NC1=NC(N)=NC(N=C2N)=C1N=C2C3=CC=CC=C3. InChi Code: InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19). InChi Key: FNYLWPVRPXGIIP-UHFFFAOYSA-N.