TPEN

As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions. Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation. At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.Formal Name: N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine. CAS Number: 16858-02-9. Synonyms: TPEDA. Molecular Formula: C26H28N6. Formula Weight: 424.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.15 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 262 nm. SMILES: c1ccc(nc1)CN(CCN(Cc1ccccn1)Cc1ccccn1)Cc1ccccn1. InChi Code: InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2. InChi Key: CVRXLMUYFMERMJ-UHFFFAOYSA-N.