Tosyl Phenylalanyl Chloromethyl Ketone

Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis. It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2. TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.Formal Name: N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-benzenesulfonamide. CAS Number: 402-71-1. Synonyms: Nalpha-Tosyl-L-Phenylalanine Chloromethyl Ketone, TPCK. Molecular Formula: C17H18ClNO3S. Formula Weight: 351.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. SMILES: CC1=CC=C(S(N[C@H](C(CCl)=O)CC2=CC=CC=C2)(=O)=O)C=C1. InChi Code: InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1. InChi Key: MQUQNUAYKLCRME-INIZCTEOSA-N.