Torin 2

Description: Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively. Target: Autophagy, ATM/ATR, mTOR, Apoptosis, DNA-PK. Smiles: Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1. References: Liu Q, et al. J Med Chem, 2011, 54(5), 1473-1480.