Toremifene (citrate)

Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen (Cay-13258). It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.Formal Name: 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine, 2-hydroxy-1,2,3-monopropanetricarboxylate. CAS Number: 89778-27-8. Synonyms: GTx-006, NK 622, NSC 613680. Molecular Formula: C26H28ClNO . C6H8O7. Formula Weight: 598.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 236, 276 nm. SMILES: ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21,7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-,. InChi Key: IWEQQRMGNVVKQW-OQKDUQJOSA-N.