Tolnaftate-d7

Tolnaftate-d7 is intended for use as an internal standard for the quantification of tolnaftate (Cay-21446) by GC- or LC-MS. Tolnaftate is a thiocarbamate antifungal agent. It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 µg/ml). Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner. It inhibits squalene epoxidase with an IC50 value of 12.5 µg/ml in a cell-free assay.Formal Name: N-methyl-N-(3-methylphenyl)-carbamothioic acid, O-(2-naphthalen-d7-yl) ester. CAS Number: 1329835-64-4. Molecular Formula: C19H10D7NOS. Formula Weight: 314.5. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: CN(C1=CC(C)=CC=C1)C(OC2=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3C([2H])=C2[2H])=S. InChi Code: InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3/i3D,4D,7D,8D,10D,11D,13D. InChi Key: FUSNMLFNXJSCDI-BTSZWIDXSA-N.