TMB 8 (hydrochloride)

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and alpha3beta4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.Formal Name: 3,4,5-trimethoxy-benzoic acid, 8-(diethylamino)octyl ester, monohydrochloride. CAS Number: 53464-72-5. Molecular Formula: C22H37NO5 . HCl. Formula Weight: 432.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: COC1=C(OC)C(OC)=CC(C(OCCCCCCCCN(CC)CC)=O)=C1.Cl. InChi Code: InChI=1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4,/h16-17H,6-15H2,1-5H3,1H. InChi Key: KFJZVXKPPQIYCG-UHFFFAOYSA-N.