TLR7 Agonist 2

TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 µM in a cell-based reporter assay. It is selective for TLR7 over TLR8 (LEC = >100 µM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-alpha levels and the IFN-stimulated gene (ISG) response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma. It increases plasma levels of IFN-alpha, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys when administered at a dose of 10 mg/kg. TLR agonist 2 (0.3-5 mg/kg) reduces serum and liver viral load in the hydrodynamic injection (HDI) hepatitis B virus (HBV) mouse model.Formal Name: 4-[(5-methyl-3-isoxazolyl)methoxy]-5-(2-pyridinylmethyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine. CAS Number: 1642857-69-9. Synonyms: Toll-Like Receptor 7 Agonist 2. Molecular Formula: C17H16N6O2. Formula Weight: 336.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 160 mg/ml. lambdamax: 232, 269, 294 nm. SMILES: NC1=NC(OCC2=NOC(C)=C2)=C3C(C=CN3CC4=NC=CC=C4)=N1. InChi Code: InChI=1S/C17H16N6O2/c1-11-8-13(22-25-11)10-24-16-15-14(20-17(18)21-16)5-7-23(15)9-12-4-2-3-6-19-12/h2-8H,9-10H2,1H3,(H2,18,20,21). InChi Key: FVKOYFLAKSGBBV-UHFFFAOYSA-N.