TLR3-IN-1

Description: TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 µM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-alpha and IL-1beta in whole cells. Target: TLR. Smiles: OC(=O)[C@@H](Cc1ccccc1)NC(=O)c1sc2cc(F)ccc2c1Cl. References: Cheng K , Wang X , Yin H . Small-Molecule Inhibitors of the TLR3/dsRNA Complex[J]. Journal of the American Chemical Society, 2011, 133(11):p.3764-3767.