Tipifarnib

Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM). It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.Formal Name: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone. CAS Number: 192185-72-1. Synonyms: R 115777. Molecular Formula: C27H22Cl2N4O. Formula Weight: 489.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 237, 285, 340 nm. SMILES: ClC1=CC=CC(C(C2=C3C=CC([C@@](C4=CC=C(Cl)C=C4)(N)C5=CN=CN5C)=C2)=CC(N3C)=O)=C1. InChi Code: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1. InChi Key: PLHJCIYEEKOWNM-HHHXNRCGSA-N.