Tienilic Acid

Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed. Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme. The time required to inactivate one half of the CYP2C10 enzyme at the maximal rate (t½max) is 3.4 minutes, with a dissociation constant (Kd) value of 4.3 µM.Formal Name: [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid. CAS Number: 40180-04-9. Molecular Formula: C13H8Cl2O4S. Formula Weight: 331.2. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml, Methanol: 1 mg/ml. lambdamax: 269, 295 nm. SMILES: O=C(C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1)C2=CC=CS2. InChi Code: InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17). InChi Key: AGHANLSBXUWXTB-UHFFFAOYSA-N.