Tie2 Inhibitor 7

Description: Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. Target: Others. Smiles: C(O)(=O)C1=CC(C2=CC=C(CN(C(OC3=CC=C(C)C=C3)=O)CC(N[C@@H](C)C4CCCCC4)=O)C=C2)=CN=C1