Tie2 Inhibitor 7

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.Formal Name: 5-[4-[[[2-[[(1S)-1-cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid. CAS Number: 1020412-97-8. Molecular Formula: C31H35N3O5. Formula Weight: 529.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 257 nm. SMILES: CC1=CC=C(C=C1)OC(N(CC(N[C@H](C2CCCCC2)C)=O)CC3=CC=C(C=C3)C4=CC(C(O)=O)=CN=C4)=O. InChi Code: InChI=1S/C31H35N3O5/c1-21-8-14-28(15-9-21)39-31(38)34(20-29(35)33-22(2)24-6-4-3-5-7-24)19-23-10-12-25(13-11-23)26-16-27(30(36)37)18-32-17-26/h8-18,22,24H,3-7,19-20H2,1-2H3,(H,33,35)(H,36,37)/t22-/m0/s1. InChi Key: GHHDFOFSMBLLDX-QFIPXVFZSA-N.