THZ1-R

THZ1-R is a non-cysteine reactive derivative of the cyclin-dependent kinase 7 (Cdk7) inhibitor THZ1 (Cay-9002215). THZ1-R inhibits Cdk7 (IC50s = 142-241 nM) less potently than THZ1 and lacks antiproliferative activity against T cell acute lymphoblastic leukemia (T-ALL) cell lines.Formal Name: N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]-benzamide. CAS Number: 1621523-07-6. Molecular Formula: C31H30ClN7O2. Formula Weight: 568.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: CN(C)CCCC(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CNC5=CC=CC=C54)=C(Cl)C=N3)=CC=C2)=O)C=C1)=O. InChi Code: InChI=1S/C31H30ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-5,7-10,12-15,17-19,33H,6,11,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38). InChi Key: TUERFPPIPKZNKE-UHFFFAOYSA-N.