Thyrotropin-Releasing Hormone

Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin. It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively). TRH (1 µM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells. In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells. In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.Formal Name: 5-oxo-L-prolyl-L-histidyl-L-prolinamide. CAS Number: 24305-27-9. Synonyms: pGlu-His-Pro amide, Thyroliberin, Thyrotropin-Releasing Factor, TRF, TRH, TSH-releasing Hormone. Molecular Formula: C16H22N6O4. Formula Weight: 362.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(N1CCC[C@H]1C(N)=O)[C@H](CC2=CNC=N2)NC([C@@H]3CCC(N3)=O)=O. InChi Code: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1. InChi Key: XNSAINXGIQZQOO-SRVKXCTJSA-N.