Thymol

Thymol is a terpenoid that has been found in T. vulgaris and has diverse biological activities. It activates transient receptor potential vanilloid 3 (TRPV3) currents in HEK293 cells expressing mouse or human TRPV3 when used at a concentration of 500 µM. Thymol is active against a variety of plant pathogenic fungi, including A. niger, A. ochraceus, Cladosporium, and F. oxysporum (MICs = 200, 125, 100, and 300 µg/ml, respectively). It is also active against the bacteria E. coli and S. aureus but not P. aeruginosa (MICs = 500, 500, and >1,000 µg/ml, respectively). Thymol inhibits lipid peroxidation in ox brain phospholipid liposomes by 45-82% when used at concentrations ranging from 0.067 to 0.664 mM and scavenges trichloromethylperoxyl (CCl3O2-) radicals. It also reduces inflammatory cell infiltration into the airway, decreases the levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid (BALF), and prevents airway hyperresponsiveness in a mouse model of ovalbumin-induced allergic asthma when administered at a dose of 16 mg/kg. Formulations containing thymol have been used as food flavorings, antiseptics, and pesticides.Formal Name: 5-methyl-2-(1-methylethyl)-phenol. CAS Number: 89-83-8. Synonyms: IPMP, p-Cymen-3-ol, 2-isopropyl-5-Methylphenol, NSC 11215, NSC 47821, NSC 49142. Molecular Formula: C10H14O. Formula Weight: 150.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: :, DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC1=CC(C)=CC=C1C(C)C. InChi Code: InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3. InChi Key: MGSRCZKZVOBKFT-UHFFFAOYSA-N. Origin: Synthetic.