Thymidine

Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base. It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate (dTMP, Cay-33549). Oral administration of thymidine in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.Formal Name: (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one. CAS Number: 50-89-5. Synonyms: 2'-deoxy Thymidine, 2'-deoxy-5-methyl-Uridine, dT, 5-Methyldeoxyuridine, NSC 21548, Thymine deoxyriboside. Molecular Formula: C10H14N2O5. Formula Weight: 242.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 266 nm. SMILES: CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)C2)C(NC1=O)=O. InChi Code: InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1. InChi Key: IQFYYKKMVGJFEH-XLPZGREQSA-N.