Thioridazine (hydrochloride)

Thioridazine is a typical antipsychotic. It binds to dopamine D2, histamine H1, M3 muscarinic, and alpha1- and alpha2-adrenergic receptors (Kis = 5-341.3 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 10-180.7 nM). Thioridazine (5 mg/kg) reduces amphetamine-induced repetitive head bobbing and oral behavior in rats. It reduces conditioned fear stress-induced freezing behavior in rats when administered at doses ranging from 3 to 100 mg/kg. Thioridazine is also active against multidrug-resistant tuberculosis in vitro and in vivo.Formal Name: 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine, monohydrochloride. CAS Number: 130-61-0. Synonyms: Aldazine, NSC 186060. Molecular Formula: C21H26N2S2 . HCl. Formula Weight: 407.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 230, 263, 316 nm. SMILES: CSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCC4N(C)CCCC4.Cl. InChi Code: InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23,/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3,1H. InChi Key: NZFNXWQNBYZDAQ-UHFFFAOYSA-N.