ThioLox

ThioLox is an inhibitor of 15-lipoxygenase 1 (15-LO-1, Ki = 3.3 µM). It also is an inhibitor of P. falciparum aspartate carbamoyltransferase (IC50 = 3.32 µM). ThioLox (50 µM) reduces LPS-induced expression of the mRNAs encoding TNF-alpha, inducible nitric oxide synthase (iNos), Il-1beta, Il-6, Il-8, and Il-12b in mouse lung slices. It inhibits increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, induced by the excitatory neurotransmitter glutamate (L-glutamic acid, Cay-30377) in mouse HT22 hippocampal cells when used at a concentration of 10 µM.Formal Name: 2-amino-N-butyl-5-phenyl-3-thiophenecarboxamide. CAS Number: 1202193-89-2. Molecular Formula: C15H18N2OS. Formula Weight: 274.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 232, 330 nm. SMILES: O=C(NCCCC)C1=C(N)SC(C2=CC=CC=C2)=C1. InChi Code: InChI=1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18). InChi Key: QWWMJRJCSZMXHZ-UHFFFAOYSA-N.