Thiamine Pyrophosphate (chloride)

Thiamine pyrophosphate (TPP) (chloride) is a metabolite of vitamin B1. It is a cofactor synthesized in the cytosol that is required for the activity of cytosolic transketolase and mitochondrial pyruvate, oxoglutarate, and branched-chain keto acid dehydrogenases. TPP (chloride) prevents hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats.Formal Name: 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-thiazolium, monochloride. CAS Number: 154-87-0. Synonyms: Cocarboxylase, TPP, Vitamin B1 Pyrophosphate. Molecular Formula: C12H19N4O7P2S . Cl. Formula Weight: 460.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Insol, DMSO: Insol, Ethanol: Insol, PBS (pH 7.2): 10 mg/mL. lambdamax: 246 nm. SMILES: CC1=NC(N)=C(C[N+]2=CSC(CCOP(OP(O)(O)=O)(O)=O)=C2C)C=N1.[Cl-]. InChi Code: InChI=1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13,/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21),1H. InChi Key: YXVCLPJQTZXJLH-UHFFFAOYSA-N.