TFAP

TFAP is an inhibitor of COX-1 (IC50 = 0.8 µM). It is selective for COX-1 over COX-2 (IC50 = 210 µM). TFAP (10 and 30 mg/kg) reduces acetic acid-induced writhing in mice and has analgesic activity in the formalin test in rats when administered at a dose of 30 mg/kg. It does not induce gastric damage in rats when administered at doses up to 300 mg/kg.Formal Name: N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-benzamide. CAS Number: 1011244-68-0. Molecular Formula: C13H10F3N3O. Formula Weight: 281.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5mg/mL, DMSO: 10mg/mL, Ethanol: 10mg/mL, Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL. lambdamax: 223, 317 nm. SMILES: O=C(NC1=CC=C(N)C=N1)C2=CC=C(C(F)(F)F)C=C2. InChi Code: InChI=1S/C13H10F3N3O/c14-13(15,16)9-3-1-8(2-4-9)12(20)19-11-6-5-10(17)7-18-11/h1-7H,17H2,(H,18,19,20). InChi Key: BTCFFMPDIBWZLF-UHFFFAOYSA-N.