Tetrahydroharmine

Tetrahydroharmine (THH) is a fluorescent indole alkaloid extracted from B. caapi, a woody vine that is used to produce a psychoactive beverage, ayahuasca, which has been ritually ingested for medicoreligious purposes throughout South America since pre-Columbian times. THH inhibits monoamine oxidase (MAO)-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 µM, respectively) compared to the companion harmala alkaloids also found in B. caapi: harmaline (Cay-10995, IC50s = 2.5 nM and 25 µM, respectively) and harmine (Cay-10010324, IC50s = 2 nM and 20 µM, respectively).Formal Name: 2,3,4,9-tetrahydro-7-methoxy-1-methyl-1H-pyrido[3,4-b]indole. CAS Number: 17019-01-1. Synonyms: Leptaflorine, THH. Molecular Formula: C13H16N2O. Formula Weight: 216.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 1.5 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 228, 271, 299 nm. SMILES: CC(NCC1)C2=C1C(C=CC(OC)=C3)=C3N2. InChi Code: InChI=1S/C13H16N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7-8,14-15H,5-6H2,1-2H3. InChi Key: ZXLDQJLIBNPEFJ-UHFFFAOYSA-N.