Terpendole C

Description: Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT, IC50 = 2.1 µM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 µM) without affecting cell growth. Target: Others. Smiles: [H][C@]12O[C@@]11[C@]([H])(CC[C@]3(C)[C@@]4(C)c5[nH]c6ccccc6c5C[C@]4([H])CC[C@@]13O)O[C@@]1([H])[C@@]2([H])O[C@@H](OC1(C)C)C=C(C)C , wU:8.9,22.26,31.38,1.0,wD:26.32,3.2,10.11,4.5,34.46,29.35,(2.12,.37,,2.78,1.76,,4.17,1.1,,4.05,2.63,,3.93,4.17,,3.8,5.7,,5.19,5.04,,6.58,4.38,,6.71,2.85,,7.98,3.72,,8.1,2.19,,8.61,3.64,,9.52,2.78,,10.32,4.1,,11.82,3.74,,13.09,4.61,,14.48,3.95,,14.6,2.42,,13.34,1.55,,11.95,2.21,,10.52,1.61,,9.72,.3,,8.22,.65,,8.51,-.86,,6.96,-.22,,5.57,.44,,5.44,1.97,,4.93,.52,,2.53,4.83,,1.27,3.95,,1.14,5.49,,1.39,2.42,,1.52,.88,,.12,1.55,,-1.27,2.21,,-1.39,3.74,,-.12,4.61,,-1.21,5.71,,.77,5.87,,-2.53,1.33,,-3.93,1.99,,-5.19,1.12,,-4.05,3.53,),