Tenovin-6 Hydrochloride

Description: Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 µM, 10 µM, and 67 µM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . Target: Autophagy, Sirtuin, p53, Dehydrogenase, HDAC. Smiles: Cl.CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1. References: Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4,6:22622.