Tenofovir diphosphate (sodium salt)

Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 µM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 µM). It is selective for these enzymes over DNA polymerase alpha and beta, as well as mitochondrial DNA polymerase gamma (Kis = 5.2, 81.7, and 59.5 µM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir (Cay-13874) and tenofovir disoproxil (Cay-16922) by nucleotide kinases. Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.Formal Name: diphosphoric acid, anhydride with [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid, sodium salt. Synonyms: PMPApp, TFV-DP. Molecular Formula: C9H16N5O10P3 . XNa. Formula Weight: 447.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Tris-HCl pH 7.5: soluble. SMILES: O=P(OP(OP(O)(O)=O)(O)=O)(O)CO[C@H](C)CN1C=NC2=C(N)N=CN=C21.[Na]. InChi Code: InChI=1S/C9H16N5O10P3.Na/c1-6(2-14-4-13-7-8(10)11-3-12-9(7)14)22-5-25(15,16)23-27(20,21)24-26(17,18)19,/h3-4,6H,2,5H2,1H3,(H,15,16)(H,20,21)(H2,10,11,12)(H2,17,18,19),/t6-,/m1./s1. InChi Key: DNEVUATVCWYSCG-FYZOBXCZSA-N.