Tenofovir alafenamide hemifumarate

Description: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Target: Reverse Transcriptase, HIV Protease. Smiles: OC(/C=C/C(O)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(OC3=CC=CC=C3)=O)=O.CC(C)OC([C@H](C)NP(CO[C@H](C)CN4C5=NC=NC(N)=C5N=C4)(OC6=CC=CC=C6)=O)=O. References: Birkus G, Bam RA, Willkom M,et al.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors[J].Antimicrob Agents Chemother. 2015 Oct 26,60(1):316-22.