Tenapanor HCl

Description: Tenapanor( AZD-1722, RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which is used for sodium handling in the gastrointestinal tract and kidney. Target: Others. Smiles: ClC1=C2C([C@H](C3=CC(S(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C4=CC([C@H]5C6=CC(Cl)=CC(Cl)=C6CN(C5)C)=CC=C4)=O)=O)=O)(=O)=O)=CC=C3)CN(C2)C)=CC(Cl)=C1.Cl.Cl. References: Johansson SA, Knutsson M, Leonsson-Zachrisson M, Rosenbaum DP. Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study. Clin Pharmacol Drug Dev. 2017 Mar 24. doi: 10.1002/cpdd.341. [Epub ahead of print] PubMed PMID: 28339149.