Temocaprilat

Temocaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 3.6 nM for rabbit lung ACE). It inhibits contraction of isolated rat aorta induced by angiotensin I (Cay-24737) with an IC50 value of 7.6 nM. Temocaprilat (1-30 µg/kg, i.v.) inhibits angiotensin I-induced pressor responses in anesthetized rats in a dose-dependent manner.Formal Name: (2S,6R)-6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid. CAS Number: 110221-53-9. Synonyms: CS 622 Diacid, RS 5139, Temocapril Diacid. Molecular Formula: C21H24N2O5S2. Formula Weight: 448.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): 5 mg/ml. lambdamax: 234 nm. SMILES: OC([C@@H](N[C@H]1CS[C@H](C2=CC=CS2)CN(CC(O)=O)C1=O)CCC3=CC=CC=C3)=O. InChi Code: InChI=1S/C21H24N2O5S2/c24-19(25)12-23-11-18(17-7-4-10-29-17)30-13-16(20(23)26)22-15(21(27)28)9-8-14-5-2-1-3-6-14/h1-7,10,15-16,18,22H,8-9,11-13H2,(H,24,25)(H,27,28)/t15-,16-,18-/m0/s1. InChi Key: KZVWEOXAPZXAFB-BQFCYCMXSA-N.