Tedizolid-13C-d3

Tedizolid-13C-d3 is intended for use as an internal standard for the quantification of tedizolid (Cay-32952) by GC- or LC-MS. Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate (Cay-23729). Tedizolid phosphate is converted to tedizolid by phosphatases in vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistant S. aureus (MRSA), E. faecalis, and penicillin-susceptible S. pneumoniae (MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptible S. aureus (MSSA) infection (ED50 = 8.8 mg/kg).Formal Name: (5R)-3-[3-fluoro-4-[6-[2-(methyl-13C-d3)-2H-tetrazol-5-yl]-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone. CAS Number: 2931763-72-1. Synonyms: TR-700-13C-d3. Molecular Formula: C16[13C]H12D3FN6O3. Formula Weight: 374.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: FC1=CC(N2C[C@H](CO)OC2=O)=CC=C1C3=CN=C(C4=NN([13C]([2H])([2H])[2H])N=N4)C=C3. InChi Code: InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1/i1+1D3. InChi Key: XFALPSLJIHVRKE-JMQKSPSZSA-N.