Tebuconazole-d9

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole (Cay-24052) by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14alpha-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17alpha-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virilizing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning the platform location in the Morris water maze. Formulations containing tebuconazole have been used as preservatives for wood and other materials, as well as fungicides in agricultural, commercial, industrial, and residential areas.Formal Name: alpha-[2-(4-chlorophenyl)ethyl]-alpha-(1,1-dimethylethyl-d9)-1H-1,2,4-triazole-1-ethanol. CAS Number: 1246818-83-6. Molecular Formula: C16H13ClD9N3O. Formula Weight: 316.9. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: ClC(C=C1)=CC=C1CCC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(O)CN2C=NC=N2. InChi Code: InChI=1S/C16H22ClN3O/c1-15(2,3)16(21,10-20-12-18-11-19-20)9-8-13-4-6-14(17)7-5-13/h4-7,11-12,21H,8-10H2,1-3H3/i1D3,2D3,3D3. InChi Key: PXMNMQRDXWABCY-GQALSZNTSA-N.