TC-O 9311

TC-O 9311 is an agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 39 nM in a calcium mobilization assay). It is selective for GPR139 over a panel of 90 additional targets. TC-O 9311 (1 µM) inhibits cell death induced by 1-methyl-4-phenylpyridinium (MPP+), but not 6-hydroxydopamine (6-OHDA, Cay-25330), in primary dopaminergic midbrain neurons.Formal Name: 3,5-dimethoxy-benzoic acid, 2-[(1-naphthalenylamino)carbonyl]hydrazide. CAS Number: 444932-31-4. Molecular Formula: C20H19N3O4. Formula Weight: 365.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14mg/mL, DMSO: 11mg/mL, Ethanol: 14mg/mL, PBS (pH 7.2): 5mg/mL. lambdamax: 221, 293 nm. SMILES: COC1=CC(OC)=CC(C(NNC(NC2=CC=CC3=C2C=CC=C3)=O)=O)=C1. InChi Code: InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25). InChi Key: KPTMSQHTGZMEFU-UHFFFAOYSA-N.