TASP 0277308

Description: TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia. Target: Others. Smiles: O(C=1N(CC)C([C@H](NS(=O)(=O)C2=CC(Cl)=C(Cl)C=C2)C)=NN1)C3=CC(=CC=C3)N4CCN(C)CC4. References: Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P 1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329