Tangeretin

Tangeretin is a polymethoxylated flavone isolated from peels of citrus fruits. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells (IC50 ~ 3 µM) and blocking p38 MAPK, JNK, and Akt activation in interleukin-1beta-stimulated human lung carcinoma A549 cells. Tangeretin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells at a concentration of 10 µM. It also inhibits growth of tumors and tumor implantation in lungs of mice inoculated with murine melanoma B16F10 cells. Tangeretin has been shown to protect against tunicamycin-induced cell death in isolated murine insulinoma MIN6 cells and in renal tubular epithelium in mice at a concentration of 10 µM. More recently, tangeretin has been found to significantly reduce serum total and LDL cholesterol and triacylglycerols in hypercholesteremic hamsters.Formal Name: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 481-53-8. Synonyms: NSC 53909, NSC 618905, Ponkanetin, Tangeritin. Molecular Formula: C20H20O7. Formula Weight: 372.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 272, 322 nm. SMILES: COc1cccc(c1)c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1. InChi Code: InChI=1S/C20H20O7/c1-22-12-8-6-7-11(9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3. InChi Key: VGGCDYAXGPXIHL-UHFFFAOYSA-N.