Tandutinib

Description: Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 µM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR. Target: c-Kit, CSF-1R, Src, FLT, PDGFR, Apoptosis. Smiles: O(C)C1=CC=2C(=NC=NC2C=C1OCCCN3CCCCC3)N4CCN(C(NC5=CC=C(OC(C)C)C=C5)=O)CC4. References: Kelly LM, et al. Cancer Cell, 2002, 1(5), 421-432.