Talaporfin (sodium salt)

Talaporfin is a photosensitizer. It induces apoptosis, DNA double-strand breaks (DSBs), and the production of reactive oxygen species (ROS) in TE-11R 5-fluorouracil-resistant esophageal squamous cell carcinoma (ESCC) cells when used at a concentration of 30 µg/ml in combination with radiation. Talaporfin (2.5, 5, and 10 mg/kg) in combination with photodynamic therapy (PDT) reduces tumor growth in a TE-11R ESCC mouse xenograft model. Formulations containing talaporfin have been used as photosensitizers in PDT for the treatment of endobronchial cancer.Formal Name: N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid, tetrasodium salt. CAS Number: 220201-34-3. Synonyms: Mono-L-aspartyl Chlorin e6, NPe6, Taporfin. Molecular Formula: C38H37N5O9 . 4Na. Formula Weight: 799.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble, Water: Slightly Soluble. SMILES: [O-]C(C[C@@H](C([O-])=O)NC(CC1=C2[C@H]([C@@H](C(C=C3NC(C(C=C)=C3C)=CC4=NC(C(CC)=C4C)=CC5=C(C)C(C([O-])=O)=C1N5)=N2)C)CCC([O-])=O)=O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C38H41N5O9.4Na/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24,,,,/h7,12-14,18,22,30,39,43H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52),,,,/q,4*+1/p-4/b24-12?,25-13-,26-12-,27-14-,28-13?,29-14?,35-23?,36-23-,,,,/t18-,22-,30-,,,,/m0..../s1. InChi Key: KPALSRNVSRWOPA-XOAVSGGJSA-J.