Tafluprost (free acid)-d4

Tafluprost (free acid)-d4 is intended for use as an internal standard for the quantification of tafluprost (free acid) (Cay-10005439) by GC- or LC-MS. Tafluprost (free acid) is an FP receptor agonist (Ki = 4 nM for the human receptor), a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), and an active metabolite of the prodrug tafluprost (Cay-10005440). It is formed from tafluprost by hydrolysis and is selective for the FP receptor over the dopamine receptor and PGE2 receptor subtypes EP1 and EP2, as well as a panel of 32 neurological receptors and transporters, at 1 µM. Tafluprost (free acid) induces constriction in isolated cat iris sphincters (EC50 = 0.6 nM). It also increases the proliferation and migration of, capillary formation by, and COX-2 levels in, human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 µM.Formal Name: 9alpha,11alpha-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic-3',3',4',4'-d4 acid. Synonyms: AFP-172-d4. Molecular Formula: C22H24D4F2O5. Formula Weight: 414.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 218, 269, 276 nm. SMILES: O[C@@H](C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC2=CC=CC=C2)[C@@H]1C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O. InChi Code: InChI=1S/C22H28F2O5/c23-22(24,15-29-16-8-4-3-5-9-16)13-12-18-17(19(25)14-20(18)26)10-6-1-2-7-11-21(27)28/h1,3-6,8-9,12-13,17-20,25-26H,2,7,10-11,14-15H2,(H,27,28)/b6-1-,13-12+/t17-,18-,19+,20-/m1/s1/i2D2,7D2. InChi Key: KIQXRQVVYTYYAZ-CFBVNRQSSA-N.