T-448 free base

Description: T-448 free base, an orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), has an IC50 of 22 nM. Target: Histone Demethylase. Smiles: N([C@H]1[C@@H](C1)C2=CC(C(NC3=NN=C(C)S3)=O)=CC=C2)C4CCC4. References: Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.