Suzetrigine

Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8, IC50 = 0.7 nM for the human channel). It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).Formal Name: 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide. CAS Number: 2649467-58-1. Synonyms: VX-548. Molecular Formula: C21H20F5N3O4. Formula Weight: 473.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(NC1=CC=NC(C(N)=O)=C1)[C@H]2[C@H](C3=C(OC)C(F)=C(F)C=C3)[C@H](C)[C@](C)(C(F)(F)F)O2. InChi Code: InChI=1S/C21H20F5N3O4/c1-9-14(11-4-5-12(22)15(23)16(11)32-3)17(33-20(9,2)21(24,25)26)19(31)29-10-6-7-28-13(8-10)18(27)30/h4-9,14,17H,1-3H3,(H2,27,30)(H,28,29,31)/t9-,14-,17+,20+/m0/s1. InChi Key: XSQUJFKRXZMOKA-PAFIKIDNSA-N.