(±)-Sulpiride

(±)-Sulpiride is an atypical antipsychotic that binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively). It is selective for dopamine D2 and D3 over D1 receptors and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 (Kis = >10,000 nM). (±)-Sulpiride (0.5 or 1 ng per animal) increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5-choice serial reaction time task (5CSRTT) when infused directly into the nucleus accumbens in a rat model of prefrontal cortex lesion-induced attentional dysfunction. It increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice when administered at doses ranging from 12.5 to 50 µmol/kg twice per day for three days. Formulations containing (±)-sulpiride have been used in the treatment of schizophrenia.Formal Name: 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide. CAS Number: 15676-16-1. Synonyms: rac-Sulpiride, RD 1403, (RS)-(±)-Sulpiride, (S)-Sulpiride. Molecular Formula: C15H23N3O4S. Formula Weight: 341.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 212 nm. SMILES: NS(C1=CC(C(NCC2N(CC)CCC2)=O)=C(OC)C=C1)(=O)=O. InChi Code: InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21). InChi Key: BGRJTUBHPOOWDU-UHFFFAOYSA-N.