Sulfamerazine (sodium salt)

Sulfamerazine is a sulfonamide antibiotic. It inhibits dihydropteroate synthase (DHPS, IC50 = 11.26 ng/ml for the S. pneumoniae enzyme) and bacterial carbonic anhydrase by ~20% when used at a concentration of 500 µM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Formulations containing sulfamerazine have been used in the treatment of coccidiosis and acute fowl cholera in poultry.Formal Name: 4-amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide, monosodium salt. CAS Number: 127-58-2. Molecular Formula: C11H11N4O2S . Na. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 268 nm. SMILES: NC1=CC=C(S([N-]C2=NC(C)=CC=N2)(=O)=O)C=C1.[Na+]. InChi Code: InChI=1S/C11H11N4O2S.Na/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10,/h2-7H,12H2,1H3,/q-1,+1. InChi Key: BSFJGCCAXDCMOX-UHFFFAOYSA-N.