Sulconazole (nitrate)

Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species. It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro. In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 with an IC50 value of 1.1 µM. Sulconazole inhibits DNA damage induced by the metabolism of styrene by bacterial CYP450cam with a Ki value of 204.2 µM in an electrochemical biosensor model. Formulations containing sulconazole have been used for the treatment of fungal infections.Formal Name: 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, mononitrate. CAS Number: 61318-91-0. Synonyms: RS 44872. Molecular Formula: C18H15Cl3N2S . HNO3. Formula Weight: 460.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 219 nm. SMILES: ClC1=CC(Cl)=CC=C1C(CN2C=NC=C2)SCC3=CC=C(Cl)C=C3.O=[N](O)=O. InChi Code: InChI=1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21,2-1(3)4/h1-9,12,18H,10-11H2,(H,2,3,4). InChi Key: CRKGMGQUHDNAPB-UHFFFAOYSA-N.